Concepedia

Impact of positive margins on outcomes of oropharyngeal squamous cell carcinoma according to p16 status

Peter Molony, Natallia Kharytaniuk, Séamus Boyle, Robbie Woods, Gerard O’Leary, Réiltín Werner, Cynthia Heffron, Linda Feeley, Patrick Sheahan

Head & Neck · 2017 · 50 citations · 25 references

DOI

Abstract

Patients with p16-positive oropharyngeal SCC and positive margins after excision maintain a low risk of recurrence despite most receiving RT alone as adjuvant treatment. These findings raise questions regarding the additional benefit of postoperative CRT in this group.

References

25

Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer

K. Kian Ang, Jonathan Harris, Richard Wheeler et al. · New England Journal of Medicine · 2010 · 6.4K citations · Full text

Human Papillomavirus and Rising Oropharyngeal Cancer Incidence in the United States

Anil K. Chaturvedi, Eric A. Engels, Ruth M. Pfeiffer et al. · Journal of Clinical Oncology · 2011 · 3.5K citations · Full text

Postoperative Concurrent Radiotherapy and Chemotherapy for High-Risk Squamous-Cell Carcinoma of the Head and Neck

Jay S. Cooper, Thomas F. Pajak, Arlene A. Forastiere et al. · New England Journal of Medicine · 2004 · 3.2K citations

Postoperative Irradiation with or without Concomitant Chemotherapy for Locally Advanced Head and Neck Cancer

Jacques Bernier, C. Domenge, Mahmut Özsahin et al. · New England Journal of Medicine · 2004 · 3.1K citations · Full text

Defining risk levels in locally advanced head and neck cancers: A comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501)

Jacques Bernier, Jay S. Cooper, Thomas F. Pajak et al. · Head & Neck · 2005 · 1.7K citations

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