Recovery of ethanol-induced <i>Akkermansia muciniphila</i> depletion ameliorates alcoholic liver disease

Abstract

Ethanol exposure diminishes intestinal <i>A. muciniphila</i> abundance in both mice and humans and can be recovered in experimental ALD by oral supplementation. <i>A. muciniphila</i> promotes intestinal barrier integrity and ameliorates experimental ALD. Our data suggest that patients with ALD might benefit from <i>A. muciniphila</i> supplementation.