First Detection of a Fosfomycin Resistance Gene, <i>fosA7</i> , in Salmonella enterica Serovar Heidelberg Isolated from Broiler Chickens

Abstract

We previously described <i>Salmonella enterica</i> serovar Heidelberg isolates harboring a chromosomal gene cluster similar to the glutathione <i>S</i>-transferase gene, a putative <i>fosA</i> gene conferring resistance to fosfomycin. Here, we show that this new gene, named <i>fosA7</i>, confers resistance to fosfomycin. The introduction of <i>fosA7</i> into the fosfomycin-susceptible <i>Salmonella enterica</i> serovar Enteritidis resulted in a substantial increase in the fosfomycin MIC. This finding increases the awareness of antibiotic resistance in <i>Salmonella</i> Heidelberg from broilers as related to the food safety and public health.