Prognostic nomogram for hepatocellular carcinoma in adolescent and young adult patients after hepatectomy

Abstract

// Wei Zhang 1 , Yifei Tan 1 , Shu Shen 1 , Li Jiang 1 , Lunan Yan 1 , Jiayin Yang 1 , Bo Li 1 , Tianfu Wen 1 , Yong Zeng 1 , Wen Tao Wang 1 and Mingqing Xu 1 1 Department of Liver Surgery, Liver Transplantation Center, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China Correspondence to: Lunan Yan, email: Yanlunan@163.com Keywords: adolescent and young adult oncology, hepatocellular carcinoma, nomogram, liver resection Received: February 25, 2017      Accepted: April 11, 2017      Published: May 23, 2017 ABSTRACT Background: Hepatocellular carcinoma (HCC) was rarely discussed in adolescent and young adult (AYA) patients. This study aimed to discuss the character of AYA HCC patients and establish an effective prognostic nomogram for patients after hepatectomy. Results: For all of the patients, the median OS was 57 months with 5-year OS rate 60.4%, and DFS was 48 months with 5-year DFS rate 51.4%. The tumor size, vascular invasion status and the pathological differentiation were the independent predictors for both OS and DFS. Except for that, gender, Neutrophil-lymphocyte ratio, HbeAg, and α-Fetoprotein were the predictors for OS. The c-index for OS prognostic nomogram was 0.75 (95% CI, 0.71 to 0.79), and c-index was 0.70 (95% CI, 0.66 to 0.74) for DFS prognostic nomogram, which was better than American Joint Commission on Cancer 2002 and 2010, Okuda staging system, the Japanese Integrated Staging system, and Tokyo staging system. Materials And Methods: This study was based on 423 AYA HCC patients (younger than 40 years old) undergoing hepatectomy in West China Hospital between 2008 to 2014. Based on the multivariate risk factors, the nomogram was constructed for predict the possibility for overall survival (OS) and disease-free survival (DFS) rate. Harrel’s concordance index (c-index) was used to compare the predictive accuracy and discriminative ability between the nomogram and eight contemporary staging systems. Conclusions: Our prognostic nomogram could accurately and preciously provide individual prediction for AYA HCC patients in OS and DFS after hepatectomy.