Androgen receptor inhibitor–induced “BRCAness” and PARP inhibition are synthetically lethal for castration-resistant prostate cancer - Concepedia

Concepedia

Publication | Open Access

Androgen receptor inhibitor–induced “BRCAness” and PARP inhibition are synthetically lethal for castration-resistant prostate cancer

DOI Full Paper Access

293

Citations

17

References

2017

Year

Likun Li, Styliani Karanika, Guang Yang, Jiangxiang Wang, Sanghee Park, Bradley M. Broom, Ganiraju C. Manyam, Wenhui Wu, Yong Luo, Spyridon P. Basourakos,

Science Signaling

Abstract

Androgen receptor inhibition induces a “BRCAness” state that may be exploited with PARP inhibitors in patients with advanced prostate cancer.

References

	Year	Citations

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