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Naldemedine versus placebo for opioid-induced constipation (COMPOSE-1 and COMPOSE-2): two multicentre, phase 3, double-blind, randomised, parallel-group trials

Opioid EpidemicParallel-group TrialsPhase 3Health SciencesPain MedicinePostoperative Pain ManagementPharmacologyAddiction MedicinePain ManagementPharmacotherapyNaldemedine Versus PlaceboMedicineAnalgesicsOpioid Use DisorderPain Research