Concepedia

Clinical Relevance and Role of Neuronal AT <sub>1</sub> Receptors in ADAM17-Mediated ACE2 Shedding in Neurogenic Hypertension

Jiaxi Xu, Srinivas Sriramula, Huijing Xia, Lisa Moreno‐Walton, Frank Culicchia, Oliver Domenig, Marko Poglitsch, Eric Lazartigues

Circulation Research · 2017 · 169 citations · 39 references

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Abstract

Our data demonstrate that angiotensin II type 1 receptors promote ADAM17-mediated ACE2 shedding in the brain of hypertensive patients, leading to a loss in compensatory activity during neurogenic hypertension.

References

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Tumor Necrosis Factor-α Convertase (ADAM17) Mediates Regulated Ectodomain Shedding of the Severe-acute Respiratory Syndrome-Coronavirus (SARS-CoV) Receptor, Angiotensin-converting Enzyme-2 (ACE2)

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Diphenyleneiodonium, an NAD(P)H Oxidase Inhibitor, also Potently Inhibits Mitochondrial Reactive Oxygen Species Production

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Brain Microglial Cytokines in Neurogenic Hypertension

Peng Shi, Carlos Díez-Freire, Joo Yun Jun et al. · Hypertension · 2010 · 381 citations · Full text