Clinical Relevance and Role of Neuronal AT <sub>1</sub> Receptors in ADAM17-Mediated ACE2 Shedding in Neurogenic Hypertension - Concepedia

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Clinical Relevance and Role of Neuronal AT <sub>1</sub> Receptors in ADAM17-Mediated ACE2 Shedding in Neurogenic Hypertension

DOI Full Paper Access

169

Citations

39

References

2017

Year

Jiaxi Xu, Srinivas Sriramula, Huijing Xia, Lisa Moreno‐Walton, Frank Culicchia, Oliver Domenig, Marko Poglitsch, Eric Lazartigues

Circulation Research

Abstract

Our data demonstrate that angiotensin II type 1 receptors promote ADAM17-mediated ACE2 shedding in the brain of hypertensive patients, leading to a loss in compensatory activity during neurogenic hypertension.

References

	Year	Citations

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