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Comparison of Simulated Microgravity and Hydrostatic Pressure for Chondrogenesis of hASC

DOI

20

Citations

0

References

2017

Year

Liliana F. Mellor, Andrew J. Steward, Rachel C. Nordberg, Michael A. Taylor, Elizabeth G. Loboa
Aerospace Medicine and Human Performance

Abstract

Our goal was to compare chondrogenic differentiation of hASC using a microgravity bioreactor and a hydrostatic pressure vessel, two commonly used bioreactors in cartilage tissue engineering. Our results indicate that CHP promotes hASC chondrogenesis and that microgravity may inhibit hASC chondrogenesis. Our findings further suggest that cartilage formation and regeneration might be compromised in space due to the lack of mechanical loading.Mellor LF, Steward AJ, Nordberg RC, Taylor MA, Loboa EG. Comparison of simulated microgravity and hydrostatic pressure for chondrogenesis of hASC. Aerosp Med Hum Perform. 2017; 88(4):377-384.