Total Synthesis of Neomarchantin A: Key Bond Constructions Performed Using Continuous Flow Methods

Abstract

A synthesis of neomarchantin A has been achieved wherein key bond constructions involving C-O or C-C bond formations were augmented via continuous flow techniques. Of note, the synthesis of neomarchantin A represents the first demonstration of catalytic macrocyclic olefin metathesis as a key step for the synthesis of a macrocyclic bisbibenzyl natural product.