Anastomotic configuration and mucosal 5-aminosalicylic acid (5-ASA) concentrations in patients with crohn's disease: a GISC study

Abstract

The different mucosal concentrations in these two groups may be explained by the difference in segmental transit time induced by the different anastomotic configurations. A slower preanastomotic transit time, demonstrated in patients with end-to-side or side-to-side anastomosis, could offer a prolonged contact time between the intestinal content and the mucosa, resulting in an increase in drug absorption.