The Journal of Antibiotics · 1989 · 19 citations · 2 references
PharmacyMedicinal ChemistryPharmaceuticsDrug DesignDrug DiscoveryStructure-activity RelationshipsAntibacterial PharmacologyNatural Product Drug DiscoveryStructure-activity Relationship AnalysisAntibiotic DiscoveryChemical PropertiesChemical Structure ClassificationNovel Antibacterial Drug Discovery
Antifungal antibiotics S-632-A1,A2,B1 and B2 were extracted with ethyl acetate from the filtered broth of Streptomyces hygroscopicus S-632 and isolated through a combination of conventional and reversed-phase silica gel column chromatography. On the basis of the spectral data, S-632-B1 and B2 were found to be new members of the glutarimide family of antibiotics. The chemical structures of these components were elucidated as two stereo-isomers of 3-(5,7-dimethyl-8,9-epoxy-2-hydroxy-4-oxo-6-decenyl)glutarimide.
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