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TGF-β <sub>1</sub> (Transforming Growth Factor-β <sub>1</sub> ) Plays a Pivotal Role in Cardiac Myofibroblast Arrhythmogenicity

DOIFull Paper Access

75

Citations

40

References

2017

Year

Nicolò Salvarani, Ange Maguy, Stefano Andrea De Simone, Michele Miragoli, Florian Jousset, Stephan Rohr
Circulation Arrhythmia and Electrophysiology

Abstract

TGF-β<sub>1</sub> profoundly alters the electrophysiological phenotype of cardiac myofibroblasts. Apart from possibly contributing to the control of cell function in general, the changes proved to be pivotal for proarrhythmic myofibroblast-cardiomyocyte crosstalk in vitro, which suggests that TGF-β<sub>1</sub> may play a potentially important role in arrhythmogenesis of the fibrotic heart.

References

YearCitations

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