Concepedia

An eco-friendly in situ activatable antibiotic via cucurbit[8]uril-mediated supramolecular crosslinking of branched polyethylenimine

Shengke Li, Nan Jiang, Wenxuan Zhao, Yuan‐Fu Ding, Ying Zheng, Lianhui Wang, Jun Zheng, Ruibing Wang

Chemical Communications · 2017 · 67 citations · 16 references

DOI

Concepts

Abstract

We report an unprecedented, eco-friendly, in situ activatable model antibiotic, phenylalanyl-polyethylenimine (PhePEI), to potentially diminish antibiotic pollution of the environment and associated antibiotic resistance. The inactive PhePEI can be reversibly activated upon supramolecular crosslinking by cucurbit[8]uril, conferring potent antibacterial activity.

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