Roles of <scp>NADPH</scp> oxidase and mitochondria in flow‐induced vasodilation of human adipose arterioles: <scp>ROS</scp>‐induced <scp>ROS</scp> release in coronary artery disease

Abstract

These findings indicate that ROS produced by NADPH oxidase are an upstream component of the mitochondria-dependent pathway contributing to flow-dependent H₂ O₂ generation and dilation in peripheral microvessels from patients with CAD. We conclude that in CAD, both mitochondria and NADPH oxidase contribute to FID through a redox mechanism in visceral arterioles.