Nickel-Catalyzed Reductive Dicarbofunctionalization of Alkenes

Abstract

An intermolecular, three-component reductive dicarbofunctionalization of alkenes is presented here. The combination of Ni catalysis with TDAE as final reductant enables the direct formation of Csp³-Csp³ and Csp³-Csp² bonds across a variety of π-systems using two different electrophiles that are sequentially activated with exquisite selectivity under mild reaction conditions.