Cp*Co^III-catalyzed directed C–H trifluoromethylthiolation of 2-phenylpyridines and 6-arylpurines

Abstract

Cp*Co^III-catalyzed directed C-H trifluoromethylthiolation using N-trifluoromethylthiodibenzenesulfonimide as an electrophilic SCF₃ source is described. 6-Arylpurines, an important structural motif in medicinal chemistry, and 2-phenylpyridines selectively afforded mono-trifluoromethylthiolated products in moderate to good yields using an inexpensive first-row transition metal catalyst.