Azacytidine-induced Chemosensitivity to Doxorubicin in Human Breast Cancer MCF7 Cells

Abstract

AzaC significantly increases the sensitivity of MCF7 cells to Dox via activation of ERK1/2, P53, BAX and caspase-3. Moreover, the inhibition of pNF-ĸB(Thr) and HSP70 might also contribute to an increase in the sensitivity of MCF7 cells to Dox.