Facile Preparation of Water‐Soluble and Cytocompatible Small‐Sized Chitosan‐Polydopamine Nanoparticles

Abstract

Abstract In this paper, a kind of novel water‐soluble chitosan‐polydopamine ( CHT‐PDA ) nanoparticles with a hydrodynamic diameter ( D h ) around 10 nm were reported by the combination of self‐polymerization of PDA and electrostatic complexation between PDA and CHT in water/ DMSO (W/D) mixture at the molar fraction of DMSO ( x DMSO = 0.37). The preparation method was efficient with a yield of 98% around. The as‐prepared water‐soluble CHT‐PDA nanoparticles exhibited effective UV ‐screen ability, enhanced visible‐light transmittance and good cytocompatibility via MTT assay, which might be used in transparent formulation for UV protection usage, especially in biological field including sun care application.