Concepedia

Exploiting intramolecular hydrogen bonding for the highly (Z)-selective & metal free synthesis of amide substituted β-aminoenones

Palaniraja Subramaniam, Chandrasekaran Ramasubbu, Selvaraj Athiramu

Green Chemistry · 2017 · 15 citations · 28 references

DOI

Concepts

Abstract

An intramolecular hydrogen bonding directed highly stereospecific, transition metal free synthetic protocol for amide substituted β-aminoenones. High stereoselectivity, excellent yields and high purity were achieved by mere filtration without column chromatographic purification.

References

28

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Abdel‐Zaher A. Elassar, Adel Abou El‐Khair · Tetrahedron · 2003 · 519 citations

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Evidence for Intramolecular N−H···O Resonance-Assisted Hydrogen Bonding in β-Enaminones and Related Heterodienes. A Combined Crystal-Structural, IR and NMR Spectroscopic, and Quantum-Mechanical Investigation

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