Revisitation of Organoaluminum Reagents Affords a Versatile Protocol for C–X (X = N, O, F) Bond-Cleavage Cross-Coupling: A Systematic Study

Abstract

A revisit of organoaluminum reagents for cross-coupling reactions has opened up several types of C–C bond formation protocols through cleavage of phenolic/alcoholic C–O and C–F and ammonium C–N bonds. Catalyzed by the commercially available NiCl2(PCy3)2 catalyst, these reactions proceed smoothly with a wide range of substrates and broad functional group compatibility, providing a versatile methodology for organoaluminum-mediated cross-coupling processes.