Serotonin Signaling Through the 5-HT _1B Receptor and NADPH Oxidase 1 in Pulmonary Arterial Hypertension

Abstract

Serotonin can induce cellular Src-related kinase-regulated Nox1-induced ROS and Nrf-2 dysregulation, contributing to increased post-translational oxidative modification of proteins and activation of redox-sensitive signaling pathways in hPASMCs, associated with mitogenic responses. 5-HT_1B receptors contribute to experimental pulmonary hypertension by inducing lung ROS production. Our results suggest that 5-HT_1B receptor-dependent cellular Src-related kinase-Nox1-pathways contribute to vascular remodeling in PAH.