Canadian Medical Association Journal · 2017 · 79 citations · 1 references
MedicineMicrobiologyPharmacologyAntimicrobial PharmacologyAntimicrobial PharmacotherapyMedical MicrobiologyAntibacterial AgentsAntibacterial PharmacologyAntibacterial PharmacotherapyAntibacterial TherapyAntibiotic ResistanceAntimicrobial TherapyAntibacterial Drug DevelopmentAntimicrobial ChemotherapyAntimicrobial Drug DevelopmentBactericidal AgentsDna Synthesis InhibitionFluoroquinolone AntibioticsNovel Antibacterial AgentsPseudomonas Species
Fluoroquinolones are bactericidal agents that inhibit DNA synthesis in bacteria. Early fluoroquinolones (e.g., ciprofloxacin) primarily target gram-negative bacteria, including Pseudomonas species. Newer agents (e.g., levofloxacin and moxifloxacin) have expanded coverage against gram-positive
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James A. Karlowsky, Daryl J. Hoban, Melanie DeCorby et al. · Antimicrobial Agents and Chemotherapy · 2006 · 168 citations · Full text