Design and synthesis of 1,2,3-triazole–etodolac hybrids as potent anticancer molecules

Abstract

A series of novel 1,2,3-triazole–etodolac hybrids (<bold>6a–l</bold>) were synthesized as potent anti-cancer molecules and the synthesis strongly relies on Huisgen's 1,3-dipolar cycloaddition between etodolac azide <bold>3</bold> and substituted terminal alkynes <bold>5a–l</bold>.