Common and rare genetic markers of lipid variation in subjects with type 2 diabetes from the ACCORD clinical trial

Abstract

Here we present findings for the largest GWAS of lipid levels in people with type 2 diabetes to date. We identified 17 statistically significant (<i>p</i> < 1 × 10^-8) associations of CV with lipid levels in 11 genes or chromosomal regions, all of which were previously identified in meta-analyses of mostly non-diabetic cohorts. We also identified 13 associations in 11 genes based on RV, several of which represent novel findings.