Drug Development and Industrial Pharmacy · 2017 · 14 citations · 42 references
PharmacyPharmaceuticsToxicologyBiomaterialsDrug DeliveryPolymer ChemistryDrug Delivery BiomaterialsNanomaterials For Drug DeliveryNanoparticle CharacterizationNanoparticle Delivery SystemsNanoparticle FormulationsPolymeric Drug Delivery SystemsDiffraction PatternsIn-vitro CharacterizationMicroparticle Delivery SystemsMicroparticle Drug DeliveryMicroparticle FormulationsMicroparticlesPolymeric MicroparticlesX-ray Diffraction Analysis
This work describes the preparation and evaluation of safe xylan-based microparticles prepared by cross-linking polymerization using sodium trimetaphosphate. The resulting microparticles were evaluated for morphology, particle size, polymer-cross-link agent interaction, and in vitro toxicity. The microparticles showed narrow monodisperse size distributions with their mean sizes being between 3.5 and 12.5 µm in dried state. FT-IR analyzes confirmed the interaction between sodium trimetaphosphate and xylan during the cross-linking process with formation of phosphate ester bonds. Additionally, the X-ray diffraction patterns and FT-IR analyzes suggested that little or no cross-linking agent remained inside the microparticles. Furthermore, the in-vitro studies using Artemia salina and human erythrocytes revealed that the microparticles are not toxic. Therefore, the overall results suggest that these xylan microparticles can be used as a platform for new drug delivery system.
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Brine Shrimp: A Convenient General Bioassay for Active Plant Constituents
Brian F. Meyer, N. R. Ferrigni, J. E. Putnam et al. · Planta Medica · 1982 · 4.8K citations