Concepedia

Metal‐Catalyzed Direct C–H Fluoroalkenylation of Pyridine <i>N</i>‐Oxides and Related Derivatives

Alexis Lehecq, Kevin Rousée, Cédric Schneider, Vincent Levacher, Christophe Hoarau, Xavier Pannecoucke, Jean‐Philippe Bouillon, Samuel Couve‐Bonnaire

European Journal of Organic Chemistry · 2017 · 16 citations · 31 references

DOI

Concepts

Abstract

The copper‐ and palladium/copper‐catalyzed direct C–H fluoroalkenylation of pyridine N ‐oxides and related heterocycles using various gem ‐bromofluoroalkenes as electrophiles is reported. The dimetallic palladium/copper process proved to be more efficient than copper catalysis, giving access to various relevant 2‐fluoroalkenylated azines.

References

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Data-Mining for Sulfur and Fluorine: An Evaluation of Pharmaceuticals To Reveal Opportunities for Drug Design and Discovery

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Palladium-Catalyzed C−H Functionalization of Pyridine <i>N</i>-Oxides: Highly Selective Alkenylation and Direct Arylation with Unactivated Arenes

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A Solution to the 2-Pyridyl Organometallic Cross-Coupling Problem:  Regioselective Catalytic Direct Arylation of Pyridine <i>N</i>-Oxides

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, , +16