Synthesis of Lipophilic Core–Shell Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>@Au Nanoparticles and Polymeric Entrapment into Nanomicelles: A Novel Nanosystem for in Vivo Active Targeting and Magnetic Resonance–Photoacoustic Dual Imaging - Concepedia

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Synthesis of Lipophilic Core–Shell Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>@Au Nanoparticles and Polymeric Entrapment into Nanomicelles: A Novel Nanosystem for in Vivo Active Targeting and Magnetic Resonance–Photoacoustic Dual Imaging

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75

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20

References

2017

Year

Ilaria Monaco, Francesca Arena, Stefania Biffi, Erica Locatelli, Barbara Bortot, Francesca La Cava, Giada M. Marini, Giovanni Maria Severini, Enzo Terreno, Mauro Comes Franchini

Bioconjugate Chemistry

Abstract

In this work, iron/silica/gold core-shell nanoparticles (Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>@Au NPs) characterized by magnetic and optical properties have been synthesized to obtain a promising theranostic platform. To improve their biocompatibility, the obtained multilayer nanoparticles have been entrapped in polymeric micelles, decorated with folic acid moieties, and tested in vivo for photoacoustic and magnetic resonance imaging detection of ovarian cancer.

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