Evaluation of the variability and safety of serum trough concentrations of vancomycin in patients admitted to the intensive care unit

Abstract

These results suggest that the fixed-dose regimen is not appropriate for ICU patients in view of the low incidence of target trough concentrations and the high incidence of supratherapeutic concentrations. The dose should be individualized based on weight, age, and renal function to improve outcomes and patient safety.