Synthesis of Gibberellic Acid Derivatives and Their Effects on Plant Growth

Abstract

A series of novel C-3-OH substituted gibberellin derivatives bearing an amide group were designed and synthesized from the natural product gibberellic acid (GA₃). Their activities on the plant growth regulation of rice and <i>Arabidopsis</i> were evaluated in vivo. Among these compounds, <b>10d</b> and <b>10f</b> exhibited appreciable inhibitory activities on rice (48.6% at 100 μmol/L) and <i>Arabidopsis</i> (41.4% at 100 μmol/L), respectively. These results provide new insights into the design and synthesis of potential plant growth regulators.