Aldosterone and Vascular Mineralocorticoid Receptors in Murine Endotoxic and Human Septic Shock*

Abstract

We found a beneficial effect of mineralocorticoids on survival, blood pressure, and vascular reactivity, associated with a restoration of α1-adrenoceptor expression in endotoxic shock. Furthermore, blunted vascular mineralocorticoid receptor expression might participate in hemodynamic failure during sepsis.