<scp>E7</scp> (<scp>1057ΔTA</scp>) mutation of the acidic α‐glucosidase gene causes Pompe's disease in Droughtmaster cattle

Abstract

The lethal mutation 1057ΔTA of GAA is present in the Droughtmaster breed, with pathology identical to that reported in pure Brahman animals. Droughtmaster breeders should take action to prevent any increase in the prevalence of this lethal allele in the breed as it could cause both welfare issues and production losses if ignored.