Applications of Synthetic Organic Tetrasulfides as H₂S Donors

Abstract

High Resolution Image Download MS PowerPoint Slide In an effort to expand the availability of simple polysulfides for H 2 S donation, we report here the synthesis and H 2 S release profiles of bis (aryl) and bis (alkyl) tetrasulfides. The tetrasulfide donors release H 2 S in a first-order dependence on reduced glutathione (GSH) and release more H 2 S than the commonly used trisulfide DATS.