A Controlled, Randomized Double-Blind Study to Evaluate the Safety and Efficacy of Chitosan- <i>N</i> -Acetylcysteine for the Treatment of Dry Eye Syndrome

Abstract

A single instillation of C-NAC significantly increased mean TFT in patients with DES as early as 10 min after instillation and lasted for 24 h. The magnitude of the increase in TFT following a single instillation was comparable with that after instillation twice daily over 5 days. Corneal damage improved in >60% of patients. C-NAC could be a viable treatment option for DES.