Punicalagin reduces H₂O₂-induced cytotoxicity and apoptosis in PC12 cells by modulating the levels of reactive oxygen species

Abstract

Results of the present study demonstrated a neuroprotective effect of punicalagin on H₂O₂-induced PC12 cell death, including mitochondria damage and expression of apoptotic gene Bax; therefore we hypothesize a possible prevent role for this molecule in neurodegenerative diseases related to oxidative stress.