Chemical Synthesis of Modified Hyaluronic Acid Disaccharides

Abstract

Abstract Herein we report a chemical synthesis towards new modified hyaluronic acid oligomers by using only commercially available d ‐glucose and d ‐glucosamine hydrochloride. The various protected hyaluronic acid disaccharides were synthesized bearing new functional groups at C‐6 of the β‐ d ‐glucuronic acid moiety with a view to structure‐related biological activity tests. The orthogonal protecting group pattern allows ready access to the corresponding higher oligomers. Also, 1 H NMR studies of the new derivatives demonstrated the effect of the various functional groups on the intramolecular electronic environment.