Radiocomplexation and bioevaluation of ^99mTc nitrido-piracetam as a model for brain imaging

Abstract

Abstract The aim of the work is to radiolabel a piracetam using [ 99m Tc≡N] 2+ core in order to give a 99m TcN-labeled piracetam complex, that is expected to concentrate in brain organ by AMPA receptors. The complex was prepared with high radiochemical purity (>98.0) and maintained stability throughout the working period (8 h) using different quality controls. Biodistribution investigation showed that, the maximum uptake of the complex in the brain was 13.5±0.12% at 5 min post injection (p.i.) of the injected dose/g which retained till 2 h post-injection.