Stereoselective Vicinal Difunctionalization of Alkynes through a Three‐Component Reaction of Alkynes, Sodium Sulfinates, and Togni Reagent

Abstract

Abstract Stereoselective vicinal difunctionalization of alkynes through trifluoromethylation and sulfonylation via a three‐component reaction of alkynes, sodium sulfinates, and Togni reagent under catalyst‐ and additive‐free conditions has been realized. This reaction proceeds at room temperature in dimethyl sulfoxide (DMSO), providing ( E )‐β‐trifluoromethylvinyl sulfones in moderate to good yields. The advantages of this tandem radical process include extremely mild conditions, excellent stereoselectivity, and easy experimental operation. magnified image