Instantaneous Conversion of [¹¹C]CO₂ to [¹¹C]CO via Fluoride‐Activated Disilane Species

Abstract

The development of a fast and novel methodology to generate carbon-11 carbon monoxide ([¹¹ C]CO) from cyclotron-produced carbon-11 carbon dioxide ([¹¹ C]CO₂ ) mediated by a fluoride-activated disilane species is described. This methodology allows up to 74 % conversion of [¹¹ C]CO₂ to [¹¹ C]CO using commercially available reagents, readily available laboratory equipment and mild reaction conditions (room temperature). As proof of utility, radiochemically pure [carbonyl-¹¹ C]N-benzylbenzamide was successfully synthesized from produced [¹¹ C]CO in up to 74 % radiochemical yield (RCY) and >99 % radiochemical purity (RCP) in ≤10 min from end of [¹¹ C]CO₂ delivery.