Forensic Sciences Research · 2017 · 38 citations · 28 references
PharmacyPharmaceutical AnalysisToxicologyAnalytical ToxicologyMass Spectrometric AnalysisWastewater TreatmentBioanalytical Method ValidationContaminant AnalysisOpioid ToxicologyToxicological Drug ScreeningWastewater CharacterizationWastewater ChemistryBiomarkers Of Cannabis ExposureCannabinoid DetectionCannabinoid Exposure AssessmentExtraction EfficiencyIllicit Drug DetectionOpioid Analytical ToxicologyTandem Mass Spectrometry AnalysisWastewater-based Drug Monitoring
-9-carboxy-tetrahydrocannabinol (THCCOOH) and THCCOOH-glucuronide) in raw-influent wastewater samples by ultra-high performance liquid chromatography-tandem mass spectrometry. Method validation included linearity (5-1 000 ng/L for opioids, 10-1 000 ng/L for cannabinoids), imprecision (<21.2%), accuracy (83%-131%), matrix effect (from -35.1% to -14.7%) and extraction efficiency (25%-84%), limit of detection (1-5 ng/L) and quantification (5-10 ng/L) and auto-sampler stability (no loss detected). River and wastewater samples were collected in triplicate from different locations in New York City and stored at -20 °C until analysis. Water from sewage overflow location tested positive for morphine (10.7 ng/L), oxycodone (4.2-23.5 ng/L), oxymorphone (4.8 ng/L) and hydromorphone (4.2 ng/L). Raw influent wastewater samples tested positive for morphine (133.0-258.3 ng/L), oxycodone (31.1-63.6 ng/L), oxymorphone (16.0-56.8 ng/L), hydromorphone (6.8-18.0 ng/L), hydrocodone (4.0-12.8 ng/L) and THCCOOH (168.2-772.0 ng/L). This method is sensitive and specific for opioids and marijuana determination in wastewater samples.
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