Preliminary Study of Molecularly Imprinted Polymer-based Potentiometric Sensor for Glucose

Abstract

Molecularly imprinted polymer (MIP) based on methacrylic acid (MAA) has been synthesized by bulk polymerization using glucose as template. Its potential application as electrode of potentiometric sensor for glucose has been studied. This study shows that potential responses of the MIP-based electrode depend on the concentration of glucose. For glucose concentration up to 7 mmol L-1, the measured potential is within the range of 72.5 to 295.8 mV. The potential response is linearly correlated to glucose concentration within the range of 0.02 mmol L-1 to 5 mmol L-1 with sensitivity of about 43.7 ± 1.6 mV/mmol L-1. As a comparison, potential response of Non Imprinted Polymer (NIP) electrode of has been measured. There is a significance difference between the two electrodes, where the NIP-based electrode shows far less sensitive potential response to glucose concentration compared to that of MIP-based electrode.