Imaging Local Diffusive Dynamics Using Diffusion Exchange Spectroscopy MRI

Abstract

The movement of water between microenvironments presents a central challenge in the physics of soft matter and porous media. Diffusion exchange spectroscopy (DEXSY) is a powerful 2D nuclear magnetic resonance method for measuring such exchange, yet it is rarely used because of its long scan time requirements. Moreover, it has never been combined with magnetic resonance imaging (MRI). Using probability theory, we vastly reduce the required data, making DEXSY MRI feasible for the first time. Experiments are performed on a composite nerve tissue phantom with restricted and free water-exchanging compartments.