Clinical manifestations of the anti-IgLON5 disease

Abstract

Patients with IgLON5 antibodies develop a characteristic sleep disorder preceded or accompanied by bulbar symptoms, gait abnormalities, oculomotor problems, and, less frequently, cognitive decline. IgG4 subclass antibodies predominate over IgG1; we confirm a strong association with the HLA-DRB1*10:01 allele.

References

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	Year	Citations
Interobserver agreement for the assessment of handicap in stroke patients. John C. van Swieten, Peter J. Koudstaal, Marieke C. Visser, Stroke DisabilityCerebrovascular DiseaseNeurological RehabilitationStroke RehabilitationStroke	1988	6.3K
A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder associated with antibodies to IgLON5: a case series, characterisation of the antigen, and post-mortem study Lídia Sabater, Carles Gaig, Ellen Gelpí, The Lancet Neurology Sleep DisordersParasomniasSleepSleep DisorderAllergy	2014	531
Neuropathological criteria of anti-IgLON5-related tauopathy Ellen Gelpí, Romana Höftberger, Francesc Graus, Acta Neuropathologica	2016	232
Cellular investigations with human antibodies associated with the anti-IgLON5 syndrome Lídia Sabater, Jesús Planagumà, Josep Dalmau, Journal of Neuroinflammation	2016	151
Sleep disorder, chorea, and dementia associated with IgLON5 antibodies Mateus Mistieri Simabukuro, Lídia Sabater, Tarso Adoni, Neurology Neuroimmunology & Neuroinflammation Sleep DisordersNovel SyndromeCorticobasal DegenerationNeurological DisorderPathology	2015	69
Determination of Neuronal Antibodies in Suspected and Definite Creutzfeldt-Jakob Disease Oriol Grau‐Rivera, Raquel Sánchez‐Valle, Albert Saiz, JAMA Neurology	2013	62
High-level gait and balance disorders in the elderly: a midbrain disease? Adèle Demain, G. W. Max Westby, Sara Fernández-Vidal, Journal of Neurology	2013	61
IgLON5 autoimmunity and abnormal behaviours during sleep Birgit Högl, Anna Heidbreder, Joan Santamaría, The Lancet Sleep DisordersSleepSleep DisorderAutoimmune DiseaseMedicine	2015	56
Allelic and haplotypic HLA frequency distribution in Spanish hematopoietic patients. Implications for unrelated donor searching A. Balas, F. García‐Sánchez, José L. Vicário Tissue Antigens	2010	51

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