Synlett · 2017 · 50 citations · 11 references
Natural SciencesChemical EngineeringChemistryComputational ChemistryNatural Product BiosynthesisOrganic ChemistryHeterocycle SynthesisHeterocyclic ChemistryHeterocyclic CompoundsReaction MechanismsCascade ReactionsHeterocyclic Natural ProductsLewis Acid CatalysisLewis Acid-base TheoryLewis AcidityNatural Product SynthesisRing-forming Reactions
The σ/π-binding properties of a series of Lewis acids was studied using DFT calculations. The results led to the identification of Zn(II)/In(III) as a suitable dual-mode Lewis acid for use in promoting cascade cyclization reactions. Based on this finding, we developed three new types of dual-mode Lewis acid induced cascade cyclization reactions and have demonstrated the utilities of each process in natural product synthesis. 1 Introduction 2 Dual-Mode Lewis Acids 3 Prins/Conia-Ene Cascade Reaction and its Applications 4 Diels–Alder/Carbocyclization Cascade Reaction and Applications 4.1 First Generation Diels–Alder/Carbocyclization Cascade Reaction and its Application 4.2 Second Generation Diels–Alder/Carbocyclization Cascade Reaction and its Applications 5 Michael/Conia-Ene Cascade Reaction and its Applications 6 Conclusion
11
Platensimycin is a selective FabF inhibitor with potent antibiotic properties
Jun Wang, S.M. Soisson, Katherine Young et al. · Nature · 2006 · 815 citations
Phomactin A; a novel PAF antagonist from a marine fungus Phoma sp
Michihiro Sugano, Aiya Sato, Yasuteru Iijima et al. · Journal of the American Chemical Society · 1991 · 162 citations
Life Sciences, Botany, Pharmacology +10
Strategies and approaches for constructing 1-oxadecalins
Yu Tang, Jossian Oppenheimer, Zhenlei Song et al. · Tetrahedron · 2006 · 109 citations