Chemogenetic Inhibition of Pain Neurons in a Mouse Model of Osteoarthritis

Abstract

Chemogenetic inhibition of Na_V 1.8-expressing neurons blocks knee hyperalgesia and mechanical allodynia in early experimental OA, but is no longer efficacious in the later stages. These data indicate that activation of inhibitory GPCRs located solely outside the central nervous system may be ineffective in treating chronic OA pain.