Incorporation of Carbon Dioxide into Carbamate Directing Groups: Palladium‐Catalyzed <i>meta</i>‐C–H Olefination and Acetoxylation of Aniline Derivatives

Abstract

Abstract Carbon dioxide (CO 2 ), a readily available, non‐toxic, and inexpensive greenhouse gas, is an ideal reagent for carbamate synthesis. For the first time, CO 2 has been efficiently incorporated into a novel nitrile‐containing directing group (DG) for meta ‐C–H activation of anilines under mild conditions. Thus, various aniline derivatives were meta ‐olefinated with palladium(II) acetate. meta ‐C–H acetoxylation was also feasible and the carbamate DG could be easily removed under basic conditions. The practicality of substrate preparation, functional group tolerance, and versatility of this method make it a valuable addition to the meta ‐C–H functionalization of anilines. magnified image