Scientific Reports · 2017 · 51 citations · 37 references
MedicineMolecular BiologyNeuroscienceDevelopmental NeuroscienceMolecular NeurobiologyMolecular NeuroscienceDendrite DevelopmentDendritic DevelopmentNeural Circuit FormationNeural DevelopmentNeurogenesisSynaptogenesisCo-repressor FunctionCortical Circuit DevelopmentNeuronal Activity SensingNeuronal MorphogenesisStructural Brain DevelopmentTranscriptional RepressionTranscriptional Repression MechanismsTranscriptional Repressors
Forkhead Box P (FOXP) transcriptional repressors play a major role in brain development and their dysfunction leads to human cognitive disorders. However, little is known about how the activity of these proteins is regulated. Here, we show that FOXP1 SUMOylation at lysine 670 is required for recruiting the co-repressor CtBP1 and transcriptional repression. FOXP1 SUMOylation is tightly controlled by neuronal activity, in which synapse to nucleus signalling, mediated via NMDAR and L-type calcium channels, results in rapid FOXP1 deSUMOylation. Knockdown of FOXP1 in cultured cortical neurons stunts dendritic outgrowth and this phenotype cannot be rescued by replacement with a non-SUMOylatable FOXP1-K670R mutant, indicating that SUMOylation of FOXP1 is essential for regulation of proper neuronal morphogenesis. These results suggest that activity-dependent SUMOylation of FOXP1 may be an important mediator of early cortical development and neuronal network formation in the brain.
37
A forkhead-domain gene is mutated in a severe speech and language disorder
Cecilia Lai, Simon E. Fisher, Jane A. Hurst et al. · Nature · 2001 · 2.1K citations · Full text
Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations
Brian J. O’Roak, Pelagia Deriziotis, Choli Lee et al. · Nature Genetics · 2011 · 1.2K citations · Full text