Contribution of the <i>TP53</i> R337H mutation to the cancer burden in southern Brazil: Insights from the study of 55 families of children with adrenocortical tumors

Abstract

TP53 R337H carriers have a lifelong predisposition to cancer with a bimodal age distribution: 1 peak, represented by ACT, occurs in the first decade of life, and another peak of diverse cancer types occurs in the fifth decade. The current findings have implications for genetic counseling and surveillance of R337H carriers. Cancer 2017;123:3150-58. © 2017 American Cancer Society.