Journal of Biochemical and Molecular Toxicology · 2017 · 26 citations · 45 references
Veterinary MedicineToxicologyVeterinary ToxicologyBiochemical ToxicologyHeavy Metal ToxicologyHepatotoxicologyChromium ToxicologyHepatotoxicity MechanismsOxidative Stress In HepatotoxicitySelenium ToxicitySelenium ToxicologyToxic DiseasesChromium HepatotoxicityChromium-induced Oxidative StressDietary Selenium ToxicityDietary Selenium ToxicologyHepatotoxicity Of SeleniumMechanisms Of Chromium ToxicityMitochondrial Membrane Potential AnalysisSelenium-induced Oxidative Stress
Abstract This study aimed to clarify the effect of selenium (Se) on chromium (VI) [Cr(VI)]‐induced damage in chicken liver. A total of 105 chickens were randomly divided into seven groups of 15. Group I received deionized water; group II received Cr(VI) (7.83 mg/kg/d) alone; and other groups orally received both Cr(VI) (7.83 mg/kg/d) and Se of different doses (0.14, 0.29, 0.57, 1.14, and 2.28 mg/kg/d). The levels of superoxide dismutase (SOD), glutathione (GSH), malondialdehyde (MDA), Ca 2+ ‐ATPase, and mitochondrial membrane potential (MMP) were measured. Results showed that Cr(VI) increased MDA content and decreased GSH content, T‐SOD activity, Ca 2+ ‐ATPase activity, and MMP level. Meanwhile, Se co‐treatment (0.14, 0.29, and 0.57 mg/kg/d) increased the viability of the above indicators compared with Cr(VI)‐treatment alone. In addition, histopathologic examination revealed that Cr(VI) can cause liver damage, whereas Se supplementation of moderate dose inhibited this damage. This study confirmed that Se exerted protective effect against Cr(VI)‐induced liver damage.
45
Cytotoxicity and oxidative mechanisms of different forms of chromium
Debasis Bagchi · Toxicology · 2002 · 658 citations