Dalton Transactions · 2017 · 103 citations · 60 references
Natural SciencesChemistryMedicinal ChemistryCancer PharmacologyDrug DiscoveryMolecular OncologyCarbene ComplexesCoordination ChemistryHeterocyclic ChemistryHeterocyclic CompoundsLigand BindingAnticancer ActivityAnticancer ChemotherapyOrganoiridium ChemistryOrganometallic Anticancer AgentsTransition Metal Carbene Complexes
concentrations of the complexes, and increase the amount of reactive oxygen species (ROS) dramatically, which appears to contribute to the anticancer activity. This class of organometallic Ir complexes has unusual features worthy of further exploration in the design of novel anticancer drugs.
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