Site-Selectivity Control in Organic Reactions: A Quest To Differentiate Reactivity among the Same Kind of Functional Groups

Abstract

On our path to the perfection of organic synthesis lies the challenge of controlling site selectivity, which is the differentiation of reactivity among the same kind of functional groups. Overcoming this challenge would significantly enhance synthetic efficiency and minimize waste production, which in turn calls for the development of new catalysts, reagents, tactics, and innovative strategies.